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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesMus musculus (Mouse)
GeneHtr1a
Synonym5-HT-1A
Gpcr18
ADRBRL1
ADRB2RL1
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
[ Show all ]
DiseaseN/A for non-human GPCRs
Length421
Amino acid sequenceMDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR
UniProtQ64264
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3737
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL128954
Molecular formulaC19H25NO
IUPAC name5-phenyl-6-piperidin-1-ylbicyclo[2.2.2]octan-2-one
Molecular weight283.415
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP3.3
Synonyms5-Phenyl-6-piperidin-1-yl-bicyclo[2.2.2]octan-2-one
BDBM50012984
Inchi KeyTWEOXNBABJCSDU-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H25NO/c21-17-13-15-9-10-16(17)19(20-11-5-2-6-12-20)18(15)14-7-3-1-4-8-14/h1,3-4,7-8,15-16,18-19H,2,5-6,9-13H2
PubChem CID44351533
ChEMBLCHEMBL128954
IUPHARN/A
BindingDB50012984
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Hill coefficient0.89 -PMID2136918ChEMBL
IC50358000.0 nMPMID2136918BindingDB,ChEMBL
Ki274000.0 nMPMID2136918BindingDB,ChEMBL

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