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Name | G-protein coupled receptor 55 |
---|---|
Species | Homo sapiens (Human) |
Gene | GPR55 |
Synonym | GPR55 |
Disease | N/A |
Length | 319 |
Amino acid sequence | MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNIRAHRPSRVQLVLQDTTISRG |
UniProt | Q9Y2T6 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y2T6 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y2T6. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1075322 |
IUPHAR | 109 |
DrugBank | BE0005802 |
Name | CHEMBL3120632 |
---|---|
Molecular formula | C29H41NO2 |
IUPAC name | (1S,12S,15R,16S,17S,20S)-16-[(E)-4-methoxy-4-methylpent-2-enyl]-1,16,20-trimethyl-3-azapentacyclo[10.8.0.02,10.04,9.015,20]icosa-2(10),4,6,8-tetraen-17-ol |
Molecular weight | 435.652 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 2 |
XlogP | 6.5 |
Synonyms | 27-O-Methylasporyzin C BDBM50448076 |
Inchi Key | TXDUYXUPRRYHRW-MYFCUFBASA-N |
Inchi ID | InChI=1S/C29H41NO2/c1-26(2,32-6)15-9-16-27(3)23-13-12-19-18-21-20-10-7-8-11-22(20)30-25(21)29(19,5)28(23,4)17-14-24(27)31/h7-11,15,19,23-24,30-31H,12-14,16-18H2,1-6H3/b15-9+/t19-,23-,24-,27-,28-,29+/m0/s1 |
PubChem CID | 76325292 |
ChEMBL | CHEMBL3120632 |
IUPHAR | N/A |
BindingDB | 50448076 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <10000.0 nM | PMID24471526 | BindingDB,ChEMBL |
Inhibition | 31.0 % | PMID24471526 | ChEMBL |
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