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GPCR

NameHistamine H2 receptor
SpeciesCavia porcellus (Guinea pig)
GeneHRH2
SynonymGastric receptor I
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProtP47747
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2882
IUPHARN/A
DrugBankN/A

Ligand

NameVUF-8406
Molecular formulaC11H18N6S
IUPAC name1-cyano-2-[3-(1H-imidazol-5-yl)propyl]-3-(2-methylsulfanylethyl)guanidine
Molecular weight266.367
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP0.7
SynonymsCHEMBL12158
BDBM50406094
Inchi KeyBUFLTNKXAJNCHK-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H18N6S/c1-18-6-5-15-11(16-8-12)14-4-2-3-10-7-13-9-17-10/h7,9H,2-6H2,1H3,(H,13,17)(H2,14,15,16)
PubChem CID44267951
ChEMBLCHEMBL12158
IUPHARN/A
BindingDB50406094
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.0 -PMID1967317ChEMBL
Kd15.85 nMPMID1967317BindingDB,ChEMBL

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