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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-X-C chemokine receptor type 5
Species	Homo sapiens (Human)
Gene	CXCR5
Synonym	BLR-1 NLR neurolymphatic receptor Monocyte-derived receptor 15 MDR15 MDR-15 Gpcr6 CXCR5 CXCR-5 CXC-R5 CD185 Burkitt lymphoma receptor 1 [ Show all ]
Disease	Systemic lupus erythematosus
Length	372
Amino acid sequence	MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
UniProt	P32302
Protein Data Bank	N/A
GPCR-HGmod model	P32302
3D structure model	This predicted structure model is from GPCR-EXP P32302.
BioLiP	N/A
Therapeutic Target Database	T09528
ChEMBL	CHEMBL1075315
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2179461
Molecular formula	C324H318F252N42P42
IUPAC name	1-[[3,5-bis[[4-[1-[[3,5-bis[[4-[1-[[3,5-bis[[4-(1-ethylpyridin-1-ium-4-yl)pyridin-1-ium-1-yl]methyl]phenyl]methyl]pyridin-1-ium-4-yl]pyridin-1-ium-1-yl]methyl]phenyl]methyl]pyridin-1-ium-4-yl]pyridin-1-ium-1-yl]methyl]phenyl]methyl]-4-[1-[[3,5-bis[[4-[1-[[3,5-bis[[4-(1-ethylpyridin-1-ium-4-yl)pyridin-1-ium-1-yl]methyl]phenyl]methyl]pyridin-1-ium-4-yl]pyridin-1-ium-1-yl]methyl]phenyl]methyl]pyridin-1-ium-4-yl]pyridin-1-ium;dotetracontahexafluorophosphate
Molecular weight	10888.9
Hydrogen bond acceptor	294
Hydrogen bond donor	0
XlogP	None
Synonyms	N/A
Inchi Key	UBDNICMSWQAGGB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C324H318N42.42F6P/c1-13-325-109-25-283(26-110-325)295-49-133-337(134-50-295)223-253-193-254(224-338-135-51-296(52-136-338)284-27-111-326(14-2)112-28-284)200-265(199-253)235-349-157-73-307(74-158-349)313-85-169-355(170-86-313)241-271-211-272(242-356-171-87-314(88-172-356)308-75-159-350(160-76-308)236-266-201-255(225-339-137-53-297(54-138-339)285-29-113-327(15-3)114-30-285)194-256(202-266)226-340-139-55-298(56-140-340)286-31-115-328(16-4)116-32-286)215-277(214-271)247-361-181-97-319(98-182-361)322-103-187-364(188-104-322)250-280-220-281(251-365-189-105-323(106-190-365)320-99-183-362(184-100-320)248-278-216-273(243-357-173-89-315(90-174-357)309-77-161-351(162-78-309)237-267-203-257(227-341-141-57-299(58-142-341)287-33-117-329(17-5)118-34-287)195-258(204-267)228-342-143-59-300(60-144-342)288-35-119-330(18-6)120-36-288)212-274(217-278)244-358-175-91-316(92-176-358)310-79-163-352(164-80-310)238-268-205-259(229-343-145-61-301(62-146-343)289-37-121-331(19-7)122-38-289)196-260(206-268)230-344-147-63-302(64-148-344)290-39-123-332(20-8)124-40-290)222-282(221-280)252-366-191-107-324(108-192-366)321-101-185-363(186-102-321)249-279-218-275(245-359-177-93-317(94-178-359)311-81-165-353(166-82-311)239-269-207-261(231-345-149-65-303(66-150-345)291-41-125-333(21-9)126-42-291)197-262(208-269)232-346-151-67-304(68-152-346)292-43-127-334(22-10)128-44-292)213-276(219-279)246-360-179-95-318(96-180-360)312-83-167-354(168-84-312)240-270-209-263(233-347-153-69-305(70-154-347)293-45-129-335(23-11)130-46-293)198-264(210-270)234-348-155-71-306(72-156-348)294-47-131-336(24-12)132-48-294;421-7(2,3,4,5)6/h25-222H,13-24,223-252H2,1-12H3;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/q+42;42-1
PubChem CID	71450127
ChEMBL	CHEMBL2179461
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5.9 ug.mL-1	PMID23157587	ChEMBL

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