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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	CHEMBL3261701
Molecular formula	C24H24Cl2N2O2
IUPAC name	3,4-dichloro-N-[4-[3-(dimethylamino)-1-phenylpropoxy]phenyl]benzamide
Molecular weight	443.368
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.9
Synonyms	BDBM50013058
Inchi Key	BUYDDOSUPDRQLT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H24Cl2N2O2/c1-28(2)15-14-23(17-6-4-3-5-7-17)30-20-11-9-19(10-12-20)27-24(29)18-8-13-21(25)22(26)16-18/h3-13,16,23H,14-15H2,1-2H3,(H,27,29)
PubChem CID	86302483
ChEMBL	CHEMBL3261701
IUPHAR	N/A
BindingDB	50013058
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	57.0 nM	PMID24717153	BindingDB
Ki	57.1 nM	PMID24717153	ChEMBL

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