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GPCR

Name	Alpha-1D adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1D
Synonym	alpha1a/d-adrenoceptor adrenergic receptor delta1 Gpcr8 Adrd1 ADRA1R ADRA1A ADRA1 Adra-1 alpha 1D-adrenoceptor alpha 1D-adrenoreceptor alpha1D-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-adrenergic receptor 1a Alpha-1D adrenoreceptor Alpha-1D adrenoceptor Alpha-1A adrenergic receptor alpha1D-AR [ Show all ]
Disease	Urinary incontinence Benign prostatic hyperplasia Congestive heart failure Diabetes Erectile dysfunction Fecal incontinence Glaucoma Hypertension Pediatric cancer Peripheral vascular disease Prostate disease Prostate hyperplasia [ Show all ]
Length	572
Amino acid sequence	MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
UniProt	P25100
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T53381
ChEMBL	CHEMBL223
IUPHAR	24
DrugBank	BE0004863, BE0000715

Ligand

Name	CHEMBL144731
Molecular formula	C35H37F2N3O4
IUPAC name	methyl 4-(3,4-difluorophenyl)-3-[[3-[(4-methoxycarbonyl-4-phenylpiperidin-1-yl)methyl]phenyl]methyl]-2,6-dimethyl-4H-pyrimidine-5-carboxylate
Molecular weight	601.695
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	4.8
Synonyms	6-(3,4-Difluoro-phenyl)-1-[3-(4-methoxycarbonyl-4-phenyl-piperidin-1-ylmethyl)-benzyl]-2,4-dimethyl-1,6-dihydro-pyrimidine-5-carboxylic acid methyl ester 1-[3-[[4-(Methoxycarbonyl)-4-phenylpiperidino]methyl]benzyl]-2,4-dimethyl-6-(3,4-difluorophenyl)-1,6-dihydropyrimidine-5-carboxylic acid methyl ester BDBM50082883 SCHEMBL6246644
Inchi Key	BVILLZIQPZNAQJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C35H37F2N3O4/c1-23-31(33(41)43-3)32(27-13-14-29(36)30(37)20-27)40(24(2)38-23)22-26-10-8-9-25(19-26)21-39-17-15-35(16-18-39,34(42)44-4)28-11-6-5-7-12-28/h5-14,19-20,32H,15-18,21-22H2,1-4H3
PubChem CID	10841296
ChEMBL	CHEMBL144731
IUPHAR	N/A
BindingDB	50082883
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	570.0 nM	PMID10579843	BindingDB,ChEMBL

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