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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL2694924
Molecular formulaC16H16N6O
IUPAC name6-[4-[2-[(4S)-2-amino-4,5-dihydro-1,3-oxazol-4-yl]ethyl]anilino]pyrazine-2-carbonitrile
Molecular weight308.345
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP1.4
SynonymsCHEMBL3656504
BDBM119164
ZINC169701171
US8673950, 31
Inchi KeyBVKWOUZQWOJNMH-ZDUSSCGKSA-N
Inchi IDInChI=1S/C16H16N6O/c17-7-14-8-19-9-15(21-14)20-12-4-1-11(2-5-12)3-6-13-10-23-16(18)22-13/h1-2,4-5,8-9,13H,3,6,10H2,(H2,18,22)(H,20,21)/t13-/m0/s1
PubChem CID56967604
ChEMBLCHEMBL3656504
IUPHARN/A
BindingDB119164
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki5.9 nM, NoneBindingDB,ChEMBL

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