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Name | Beta-1 adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRB1 |
Synonym | Adrenergic receptor beta 1 Adrb-1 ADRB1R adrenergic receptor beta 1-AR [ Show all ] |
Disease | Heart failure; Cardiogenic shock Heart failure Glaucoma Diabetes Coronary artery disease [ Show all ] |
Length | 477 |
Amino acid sequence | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV |
UniProt | P08588 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08588 |
3D structure model | This predicted structure model is from GPCR-EXP P08588. |
BioLiP | N/A |
Therapeutic Target Database | T44068 |
ChEMBL | CHEMBL213 |
IUPHAR | 28 |
DrugBank | BE0000172 |
Name | Tbhpbo |
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Molecular formula | C14H21N3O3 |
IUPAC name | 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one |
Molecular weight | 279.34 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 4 |
XlogP | 0.5 |
Synonyms | BDBM25747 CGP-12177A D01RRT KBio2_002438 NCGC00015184-03 [ Show all ] |
Inchi Key | UMQUQWCJKFOUGV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H21N3O3/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19) |
PubChem CID | 2687 |
ChEMBL | CHEMBL420746 |
IUPHAR | 532, 5387 |
BindingDB | 25747, 50027879 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 58.2 % | PMID23614528 | ChEMBL |
EC50 | 12.0 nM | PMID23614528 | BindingDB |
EC50 | 12.3 nM | PMID23614528 | ChEMBL |
Kd | 0.62 nM | PMID15655528 | BindingDB |
Ki | 0.398107 nM | PMID10079020 | IUPHAR |
Ki | 0.501187 - 1.58489 nM | PMID15060759, PMID15655528 | IUPHAR |
Ki | 4.5 nM | PMID14730417 | PDSP,BindingDB |
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