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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin D2 receptor
Species	Mus musculus (Mouse)
Gene	Ptgdr
Synonym	prostanoid DP receptor-like Prostanoid DP receptor prostaglandin D2 receptor (DP) PGD2 receptor PGD receptor DP1 receptor DP1 PTGDR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MNESYRCQTSTWVERGSSATMGAVLFGAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNQSLKELLPASGNQLCETFAFLMSFFGLASTLQLLAMAVECWLSLGHPFFYQRHVTLRRGVLVAPVVAAFCLAFCALPFAGFGKFVQYCPGTWCFIQMIHKERSFSVIGFSVLYSSLMALLVLATVVCNLGAMYNLYDMHRRQRHYPHRCSRDRAQSGSDYRHGSLHPLEELDHFVLLALMTVLFTMCSLPLIYRAYYGAFKLENKAEGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKVFTRPLIYRNWSSHSQQSNVESTL
UniProt	P70263
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3933
IUPHAR	338
DrugBank	N/A

Ligand

Name	CHEMBL182572
Molecular formula	C22H23NO4
IUPAC name	2-[1-(4-butoxybenzoyl)-2-methylindol-3-yl]acetic acid
Molecular weight	365.429
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.9
Synonyms	BDBM50150966 [1-(4-Butoxy-benzoyl)-2-methyl-1H-indol-3-yl]-acetic acid
Inchi Key	UOSTZGUQPUPGOE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H23NO4/c1-3-4-13-27-17-11-9-16(10-12-17)22(26)23-15(2)19(14-21(24)25)18-7-5-6-8-20(18)23/h5-12H,3-4,13-14H2,1-2H3,(H,24,25)
PubChem CID	11187675
ChEMBL	CHEMBL182572
IUPHAR	N/A
BindingDB	50150966
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	300.0 nM	PMID15357992	BindingDB,ChEMBL
IC50	3900.0 nM	PMID15357992	BindingDB,ChEMBL
Ki	10.0 nM	PMID15357992	BindingDB,ChEMBL
Ki	110.0 nM	PMID15357992	BindingDB,ChEMBL

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