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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesRattus norvegicus (Rat)
GeneHtr7
SynonymGPRFO
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
5-HTx
5-HT7 receptor
5-HT7
[ Show all ]
DiseaseN/A for non-human GPCRs
Length448
Amino acid sequenceMMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProtP32305
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3223
IUPHAR12
DrugBankN/A

Ligand

NameSCHEMBL2272950
Molecular formulaC20H23NO2
IUPAC name3-[2-cyclobutyloxy-5-(2-methylphenyl)phenoxy]azetidine
Molecular weight309.409
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.2
SynonymsBDBM105025
CHEMBL3640583
US8575364, 34
Inchi KeyBVZOFYHMVRILMN-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H23NO2/c1-14-5-2-3-8-18(14)15-9-10-19(22-16-6-4-7-16)20(11-15)23-17-12-21-13-17/h2-3,5,8-11,16-17,21H,4,6-7,12-13H2,1H3
PubChem CID46205042
ChEMBLCHEMBL3640583
IUPHARN/A
BindingDB105025
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki666.96 nM, NoneBindingDB,ChEMBL

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