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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP3 subtype
Species	Homo sapiens (Human)
Gene	PTGER3
Synonym	EP3 receptor PGE receptor EP3 subtype PGE2 receptor EP3 subtype PGE2-R prostaglandin E receptor 3 Prostanoid EP3 receptor [ Show all ]
Disease	Pain Peripheral vascular disease Asthma Glaucoma
Length	390
Amino acid sequence	MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
UniProt	P43115
Protein Data Bank	6m9t
GPCR-HGmod model	P43115
3D structure model	This structure is from PDB ID 6m9t.
BioLiP	BL0434681
Therapeutic Target Database	T85467
ChEMBL	CHEMBL3710
IUPHAR	342
DrugBank	BE0002375

Ligand

Name	CHEMBL434247
Molecular formula	C29H26O3
IUPAC name	2-methyl-3-[2-[3-(2-phenylmethoxyphenyl)phenyl]phenyl]propanoic acid
Molecular weight	422.524
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	7.0
Synonyms	3-(2''''-Benzyloxy-[1,1'';3'',1'''']terphenyl-2-yl)-2-methyl-propionic acid BDBM50134511 alpha-Methyl-2''-(benzyloxy)-1,1':3',1''-terbenzene-2-propionic acid
Inchi Key	BWEWSCNBSSRZNC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H26O3/c1-21(29(30)31)18-23-12-5-6-15-26(23)24-13-9-14-25(19-24)27-16-7-8-17-28(27)32-20-22-10-3-2-4-11-22/h2-17,19,21H,18,20H2,1H3,(H,30,31)
PubChem CID	21362849
ChEMBL	CHEMBL434247
IUPHAR	N/A
BindingDB	50134511
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	820.0 nM	PMID14552786	ChEMBL
Ki	820.0 nM	PMID14552786	BindingDB

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