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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Free fatty acid receptor 1
Species	Mus musculus (Mouse)
Gene	Ffar1
Synonym	FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40
Disease	N/A for non-human GPCRs
Length	300
Amino acid sequence	MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK
UniProt	Q76JU9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5411
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1777867
Molecular formula	C16H13BrN2O3
IUPAC name	3-[4-(5-bromopyrimidin-2-yl)oxyphenyl]hex-4-ynoic acid
Molecular weight	361.195
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.1
Synonyms	BDBM50344074 rac-3-(4-(5-bromopyrimidin-2-yloxy)phenyl)hex-4-ynoic acid
Inchi Key	USGBHZYCIIHVDP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13BrN2O3/c1-2-3-12(8-15(20)21)11-4-6-14(7-5-11)22-16-18-9-13(17)10-19-16/h4-7,9-10,12H,8H2,1H3,(H,20,21)
PubChem CID	54582631
ChEMBL	CHEMBL1777867
IUPHAR	N/A
BindingDB	50344074
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1484.0 nM	PMID21514824	BindingDB,ChEMBL

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