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GPCR

NameMu-type opioid receptor
SpeciesCavia porcellus (Guinea pig)
GeneOPRM1
SynonymM-OR-1
MOR-1
DiseaseN/A for non-human GPCRs
Length98
Amino acid sequenceYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
UniProtP97266
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4354
IUPHARN/A
DrugBankN/A

Ligand

Namemethadone
Molecular formulaC21H27NO
IUPAC name6-(dimethylamino)-4,4-diphenylheptan-3-one
Molecular weight309.453
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP3.9
SynonymsMethadona [Spanish]
AN 148
Methadonum
CAS_5967-73-7
NSC_22266
[ Show all ]
Inchi KeyUSSIQXCVUWKGNF-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3
PubChem CID4095
ChEMBLCHEMBL651
IUPHAR5458
BindingDB82507
DrugBankDB00333

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED50<50.0 mg.kg-1PMID7097722ChEMBL
ED500.4 mg.kg-1PMID7097722ChEMBL
Ki1.4 nMPMID9686407BindingDB

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