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GPCR

NameGonadotropin-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGnrhr
Synonymluteinizing hormone-releasing hormone (LHRH) receptor
luliberin receptor
LHRHR
LHRH receptor
GNRHR1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length327
Amino acid sequenceMANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProtP30969
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3066
IUPHAR256
DrugBankN/A

Ligand

NameCHEMBL2371522
Molecular formulaC74H92Cl2N18O14
IUPAC name(1S,7S,10S,15S,18S,23S,30S,33R)-15-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-23-[(4-chlorophenyl)methyl]-33-[3-(diaminomethylideneamino)propyl]-30-(2-methylpropyl)-2,8,13,16,21,24,29,32,35-nonaoxo-3,9,12,17,22,25,28,31,34-nonazatricyclo[16.9.8.03,7]pentatriacontane-10-carboxamide
Molecular weight1528.56
Hydrogen bond acceptor16
Hydrogen bond donor15
XlogP1.9
SynonymsN/A
Inchi KeyBWIRLTFDQRYWIY-XPXMVXLFSA-N
Inchi IDInChI=1S/C74H92Cl2N18O14/c1-40(2)31-53-67(102)88-52-26-29-81-64(99)54(33-42-15-20-48(75)21-16-42)85-61(96)25-24-51(66(101)86-50(65(100)89-53)12-7-28-82-74(78)79)87-71(106)58(37-62(97)83-39-59(63(77)98)93-72(107)60-13-8-30-94(60)73(52)108)92-70(105)57(36-45-9-6-27-80-38-45)91-69(104)56(34-43-17-22-49(76)23-18-43)90-68(103)55(84-41(3)95)35-44-14-19-46-10-4-5-11-47(46)32-44/h4-6,9-11,14-23,27,32,38,40,50-60H,7-8,12-13,24-26,28-31,33-37,39H2,1-3H3,(H2,77,98)(H,81,99)(H,83,97)(H,84,95)(H,85,96)(H,86,101)(H,87,106)(H,88,102)(H,89,100)(H,90,103)(H,91,104)(H,92,105)(H,93,107)(H4,78,79,82)/t50-,51+,52+,53+,54+,55-,56-,57-,58+,59+,60+/m1/s1
PubChem CID73347086
ChEMBLCHEMBL2371522
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.23 nMPMID10715147ChEMBL

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