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GPCR

Name	Free fatty acid receptor 1
Species	Homo sapiens (Human)
Gene	FFAR1
Synonym	FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor
Disease	Type 2 diabetes Non-insulin dependent diabetes Diabetes
Length	300
Amino acid sequence	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProt	O14842
Protein Data Bank	5tzy, 5tzr
GPCR-HGmod model	O14842
3D structure model	This structure is from PDB ID 5tzy.
BioLiP	BL0380462, BL0380463, BL0380464
Therapeutic Target Database	T25608
ChEMBL	CHEMBL4422
IUPHAR	225
DrugBank	BE0000688

Ligand

Name	CHEMBL1688458
Molecular formula	C22H20O4
IUPAC name	3-[4-[(3-phenoxyphenyl)methoxy]phenyl]propanoic acid
Molecular weight	348.398
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.7
Synonyms	BDBM50339461 SCHEMBL1745467 3-{4-[(3-Phenoxybenzyl)oxy]phenyl}propanoic Acid
Inchi Key	BWNUDKFBKGPSBH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H20O4/c23-22(24)14-11-17-9-12-19(13-10-17)25-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15H,11,14,16H2,(H,23,24)
PubChem CID	23136363
ChEMBL	CHEMBL1688458
IUPHAR	N/A
BindingDB	50339461
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	34.0 nM	PMID21319751	BindingDB,ChEMBL
EC50	57.54 nM	PMID24900217	ChEMBL
EC50	63.1 nM	PMID22519963	BindingDB,ChEMBL
Efficacy	90.0 %	PMID22519963	ChEMBL
Efficacy	98.0 %	PMID24900217	ChEMBL

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