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GPCR

NameType-1 angiotensin II receptor
SpeciesCavia porcellus (Guinea pig)
GeneAGTR1
SynonymAngiotensin II type-1 receptor
AT1
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
UniProtQ9WV26
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1671613
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL336056
Molecular formulaC25H19N5
IUPAC name2-methyl-4-[(E)-2-[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]ethenyl]quinoline
Molecular weight389.462
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.7
Synonyms2-Methyl-4-{2-[2''-(1H-tetrazol-5-yl)-biphenyl-4-yl]-vinyl}-quinoline
BDBM50003397
2-Methyl-4-[2-[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]ethenyl]quinoline
Inchi KeyUVEACIMNWJCOEQ-NTCAYCPXSA-N
Inchi IDInChI=1S/C25H19N5/c1-17-16-20(22-7-4-5-9-24(22)26-17)15-12-18-10-13-19(14-11-18)21-6-2-3-8-23(21)25-27-29-30-28-25/h2-16H,1H3,(H,27,28,29,30)/b15-12+
PubChem CID10455118
ChEMBLCHEMBL336056
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501300.0 nMPMID1433210ChEMBL

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