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GPCR

NameD(2) dopamine receptor
SpeciesCanis lupus familiaris (Dog)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length443
Amino acid sequenceMDPLNLSWYDDDLESQNWSRPFNGSEGKPGKPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTERSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTADSPAKPEKNGHAKDHPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCECNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtQ9GJU1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2703
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL289070
Molecular formulaC18H24ClN3O3
IUPAC nameN-[7-chloro-4-[2-(diethylamino)ethyl]-2,3-dimethyl-5-oxo-1,4-benzoxazepin-8-yl]formamide
Molecular weight365.858
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.5
SynonymsBDBM50023859
N-[7-Chloro-4-(2-diethylamino-ethyl)-2,3-dimethyl-5-oxo-4,5-dihydro-benzo[f][1,4]oxazepin-8-yl]-formamide
Inchi KeyUVSZNGCSQZOGAF-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H24ClN3O3/c1-5-21(6-2)7-8-22-12(3)13(4)25-17-10-16(20-11-23)15(19)9-14(17)18(22)24/h9-11H,5-8H2,1-4H3,(H,20,23)
PubChem CID14116960
ChEMBLCHEMBL289070
IUPHARN/A
BindingDB50023859
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED50<3.0 mg.kg-1PMID3397992ChEMBL

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