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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameBDBM50104035
Molecular formulaC151H228N44O47S
IUPAC name(3S)-3-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,5S,8S,11S,20S)-20-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-8-(4-aminobutyl)-5-(hydroxymethyl)-2-[(4-hydroxyphenyl)methyl]-3,6,9,14,21-pentaoxo-1,4,7,10,15-pentazacyclohenicosane-11-carbonyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Molecular weight3443.81
Hydrogen bond acceptor53
Hydrogen bond donor54
XlogP-16.5
SynonymsHis-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Lys-Tyr-Ser-Lys-Glu-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
Inchi KeyUWWOSPAQIBZDDF-ACYFDGKGSA-N
Inchi IDInChI=1S/C151H228N44O47S/c1-72(2)54-97(133(225)177-96(48-53-243-11)132(224)184-103(61-113(157)207)141(233)195-121(78(10)202)149(241)242)180-136(228)102(59-82-64-166-87-31-19-18-30-85(82)87)183-130(222)94(42-46-112(156)206)178-146(238)118(74(5)6)193-139(231)100(56-79-26-14-12-15-27-79)182-137(229)104(62-116(210)211)185-129(221)93(41-45-111(155)205)170-122(214)75(7)169-125(217)90(34-24-51-164-150(158)159)171-127(219)91(35-25-52-165-151(160)161)174-144(236)108(69-198)190-138(230)105(63-117(212)213)186-134(226)98(55-73(3)4)179-131(223)95-43-47-114(208)163-50-23-21-33-89(128(220)181-99(58-81-36-38-84(203)39-37-81)135(227)189-107(68-197)143(235)172-88(126(218)176-95)32-20-22-49-152)173-145(237)109(70-199)191-148(240)120(77(9)201)194-140(232)101(57-80-28-16-13-17-29-80)187-147(239)119(76(8)200)192-115(209)66-167-124(216)92(40-44-110(154)204)175-142(234)106(67-196)188-123(215)86(153)60-83-65-162-71-168-83/h12-19,26-31,36-39,64-65,71-78,86,88-109,118-121,166,196-203H,20-25,32-35,40-63,66-70,152-153H2,1-11H3,(H2,154,204)(H2,155,205)(H2,156,206)(H2,157,207)(H,162,168)(H,163,208)(H,167,216)(H,169,217)(H,170,214)(H,171,219)(H,172,235)(H,173,237)(H,174,236)(H,175,234)(H,176,218)(H,177,225)(H,178,238)(H,179,223)(H,180,228)(H,181,220)(H,182,229)(H,183,222)(H,184,224)(H,185,221)(H,186,226)(H,187,239)(H,188,215)(H,189,227)(H,190,230)(H,191,240)(H,192,209)(H,193,231)(H,194,232)(H,195,233)(H,210,211)(H,212,213)(H,241,242)(H4,158,159,164)(H4,160,161,165)/t75-,76+,77+,78+,86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-/m0/s1
PubChem CID91931738
ChEMBLCHEMBL269490
IUPHARN/A
BindingDB50104035
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.23 %PMID11543679ChEMBL
IC50652.0 nMPMID11543679BindingDB,ChEMBL

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