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GPCR

NameMu-type opioid receptor
SpeciesCavia porcellus (Guinea pig)
GeneOPRM1
SynonymM-OR-1
MOR-1
DiseaseN/A for non-human GPCRs
Length98
Amino acid sequenceYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
UniProtP97266
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4354
IUPHARN/A
DrugBankN/A

Ligand

Namenaloxone
Molecular formulaC19H21NO4
IUPAC name(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular weight327.38
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.1
SynonymsN-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon
17-Allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one
Naloxona [INN-Spanish]
4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one
Narcan
[ Show all ]
Inchi KeyUZHSEJADLWPNLE-GRGSLBFTSA-N
Inchi IDInChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
PubChem CID5284596
ChEMBLCHEMBL80
IUPHAR1638, 1676
BindingDB54795, 50000788
DrugBankDB01183

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
% recovery0.0 -PMID1320121ChEMBL
% recovery100.0 -PMID1320121ChEMBL
IC508.9 nMPMID1335078, PMID1320121BindingDB,ChEMBL
Kd1.862 nMPMID11133082ChEMBL
Kd3.162 nMPMID8057274ChEMBL
Kd3.2 nMPMID8057274BindingDB
Ke1.38 nMPMID7562933ChEMBL
Ke1.45 nMPMID7562933ChEMBL
Ke2.2 nMPMID8410999, PMID2828619ChEMBL
Ki0.68 nMPMID11495592BindingDB
Ki0.68 nMPMID17420073, PMID11495592BindingDB,ChEMBL
Ki1.1 nMPMID7932535BindingDB,ChEMBL
Ki1.5 nMPMID9686407BindingDB
Ki2.1 nMPMID26411794BindingDB,ChEMBL
Ki2.34 nMPMID6248635BindingDB

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