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GPCR

NameFollicle-stimulating hormone receptor
SpeciesHomo sapiens (Human)
GeneFSHR
SynonymFollitropin receptor
FSH receptor
FSH-R
LGR1
DiseaseFemale infertility
African trypanosomiasis
Contraception
Ovarian cancer
Length695
Amino acid sequenceMALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
UniProtP23945
Protein Data Bank4mqw
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4mqw.
BioLiPBL0274372
Therapeutic Target DatabaseT68334
ChEMBLCHEMBL2024
IUPHARN/A
DrugBankBE0000387

Ligand

NameCHEMBL47420
Molecular formulaC28H38N2O4
IUPAC name(3S)-3-[[4-(3,4-dimethoxyphenyl)phenyl]methyl]-4-methyl-1-octylpiperazine-2,5-dione
Molecular weight466.622
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP6.0
SynonymsBDBM50142659
SCHEMBL6141030
(S)-3-(3'',4''-Dimethoxy-biphenyl-4-ylmethyl)-4-methyl-1-octyl-piperazine-2,5-dione
Inchi KeyVBAAFRRDHYAHEC-DEOSSOPVSA-N
Inchi IDInChI=1S/C28H38N2O4/c1-5-6-7-8-9-10-17-30-20-27(31)29(2)24(28(30)32)18-21-11-13-22(14-12-21)23-15-16-25(33-3)26(19-23)34-4/h11-16,19,24H,5-10,17-18,20H2,1-4H3/t24-/m0/s1
PubChem CID44293018
ChEMBLCHEMBL47420
IUPHARN/A
BindingDB50142659
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC503300.0 nMPMID15026057BindingDB,ChEMBL

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