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GPCR

NameD(4) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD4
SynonymDopamine D4 receptor
dopamine receptor 4
D4R
d(2C) dopamine receptor
D4 receptor
DiseaseErectile dysfunction
Psychotic disorders
Schizophrenia
Length467
Amino acid sequenceMGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProtP21917
Protein Data Bank5wiu, 5wiv
GPCR-HGmod modelP21917
3D structure modelThis structure is from PDB ID 5wiu.
BioLiPBL0394824, BL0394825, BL0394826
Therapeutic Target DatabaseT24983
ChEMBLCHEMBL219
IUPHAR217
DrugBankBE0009376, BE0000389

Ligand

NameCHEMBL64508
Molecular formulaC15H17NO2
IUPAC name3-[2-(benzylamino)ethoxy]phenol
Molecular weight243.306
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP2.6
Synonyms3-(2-Benzylamino-ethoxy)-phenol
3-[2-(benzylamino)ethoxy]phenol
BDBM50069914
D0O4BC
Inchi KeyVBTFJGYCISLKEQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H17NO2/c17-14-7-4-8-15(11-14)18-10-9-16-12-13-5-2-1-3-6-13/h1-8,11,16-17H,9-10,12H2
PubChem CID11776546
ChEMBLCHEMBL64508
IUPHARN/A
BindingDB50069914
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki80.6 nMPMID9871673, PMID10498215ChEMBL
Ki81.0 nMPMID10498215, PMID9871673BindingDB

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