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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameSCHEMBL3618561
Molecular formulaC11H13ClN2O
IUPAC name(4S)-4-(4-chlorophenyl)-4-ethyl-5H-1,3-oxazol-2-amine
Molecular weight224.688
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP2.3
SynonymsBDBM109538
CHEMBL3684883
US8604061, 313
Inchi KeyBXMDSOIMGFAJII-LLVKDONJSA-N
Inchi IDInChI=1S/C11H13ClN2O/c1-2-11(7-15-10(13)14-11)8-3-5-9(12)6-4-8/h3-6H,2,7H2,1H3,(H2,13,14)/t11-/m1/s1
PubChem CID59323708
ChEMBLCHEMBL3684883
IUPHARN/A
BindingDB109538
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki5.0 nM, NoneBindingDB,ChEMBL

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