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GPCR

NameC-X-C chemokine receptor type 3
SpeciesMus musculus (Mouse)
GeneCxcr3
SynonymIP-10 receptor
Interferon-inducible protein 10 receptor
GPR9
G protein-coupled receptor 9
CXCR3
[ Show all ]
DiseaseN/A for non-human GPCRs
Length367
Amino acid sequenceMYLEVSERQVLDASDFAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPALYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAVQWVFGPGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPRVRVALTCIVVWGLCLLFALPDFIYLSANYDQRLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVAAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFREQMWMLFTRLGRSDQRGPQRQPSSSRRESSWSETTEASYLGL
UniProtO88410
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5200
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL255583
Molecular formulaC27H26Cl2N4O2
IUPAC nameN-[3-[7-chloro-3-[2-(4-chlorophenyl)-2-oxoethyl]-2-iminobenzimidazol-1-yl]propyl]-N-methyl-2-phenylacetamide
Molecular weight509.431
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.1
SynonymsBDBM50375126
SCHEMBL14373400
Inchi KeyVDCBVWYXKRWDEB-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H26Cl2N4O2/c1-31(25(35)17-19-7-3-2-4-8-19)15-6-16-32-26-22(29)9-5-10-23(26)33(27(32)30)18-24(34)20-11-13-21(28)14-12-20/h2-5,7-14,30H,6,15-18H2,1H3
PubChem CID44453267
ChEMBLCHEMBL255583
IUPHARN/A
BindingDB50375126
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501400.0 nMPMID18337097BindingDB,ChEMBL

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