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GPCR

NameMetabotropic glutamate receptor 3
SpeciesHomo sapiens (Human)
GeneGRM3
SynonymGPRC1C
mGluR3
mGlu3 receptor
glutamate receptor
DiseaseAlzheimer disease; Major depressive disorder
Anxiety disorder
Schizophrenia
Length879
Amino acid sequenceMKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProtQ14832
Protein Data Bank3sm9, 6b7h, 4xar, 5cnk, 5cnm
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 3sm9.
BioLiPBL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561
Therapeutic Target DatabaseT02719
ChEMBLCHEMBL2888
IUPHAR291
DrugBankN/A

Ligand

NameCHEMBL2112634
Molecular formulaC15H17NO6
IUPAC name3-[3-amino-3-carboxy-3-[(1S,2S)-2-carboxycyclopropyl]propyl]benzoic acid
Molecular weight307.302
Hydrogen bond acceptor7
Hydrogen bond donor4
XlogP-1.8
SynonymsBDBM50408697
Inchi KeyBXXBSWCSRUMEJU-AKABHXMESA-N
Inchi IDInChI=1S/C15H17NO6/c16-15(14(21)22,11-7-10(11)13(19)20)5-4-8-2-1-3-9(6-8)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)(H,21,22)/t10-,11-,15?/m0/s1
PubChem CID10828532
ChEMBLCHEMBL2112634
IUPHARN/A
BindingDB50408697
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5080.0 nMPMID9464367BindingDB,ChEMBL

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