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GPCR

NameD(2) dopamine receptor
SpeciesBos taurus (Bovine)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP20288
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3998
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL522639
Molecular formulaC17H20N6
IUPAC name6-[2-(4-pyrimidin-2-ylpiperazin-1-yl)ethyl]-1H-benzimidazole
Molecular weight308.389
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.0
SynonymsBDBM50264570
4-[2-(1H-Benzimidazol-5-yl)ethyl]-1-(2-pyrimidinyl)piperazine
6-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole
Inchi KeyBYBGXCUBCMYKCQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H20N6/c1-5-18-17(19-6-1)23-10-8-22(9-11-23)7-4-14-2-3-15-16(12-14)21-13-20-15/h1-3,5-6,12-13H,4,7-11H2,(H,20,21)
PubChem CID44579933
ChEMBLCHEMBL522639
IUPHARN/A
BindingDB50264570
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID18006194BindingDB,ChEMBL

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