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GPCR

NameNociceptin receptor
SpeciesMus musculus (Mouse)
GeneOprl1
SynonymNOP receptor
NOP-r
NOPr
OP4
ORGC
[ Show all ]
DiseaseN/A for non-human GPCRs
Length367
Amino acid sequenceMESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProtP35377
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621
IUPHAR320
DrugBankN/A

Ligand

NameH-FGGFTGARKSARKAANQA-NH2
Molecular formulaC79H129N29O22
IUPAC name(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]propanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-N-[(2S)-1-amino-1-oxopropan-2-yl]pentanediamide
Molecular weight1837.08
Hydrogen bond acceptor27
Hydrogen bond donor29
XlogP-10.9
SynonymsBDBM50333107
Inchi KeyVJNROHIAWTXNHM-FTNDTLFTSA-N
Inchi IDInChI=1S/C79H129N29O22/c1-40(63(85)116)96-70(123)53(27-28-57(83)111)105-74(127)55(35-58(84)112)106-67(120)43(4)97-64(117)42(3)98-69(122)49(23-13-15-29-80)103-71(124)52(26-18-32-91-79(88)89)102-66(119)44(5)99-76(129)56(39-109)107-73(126)50(24-14-16-30-81)104-72(125)51(25-17-31-90-78(86)87)101-65(118)41(2)95-60(114)38-94-77(130)62(45(6)110)108-75(128)54(34-47-21-11-8-12-22-47)100-61(115)37-92-59(113)36-93-68(121)48(82)33-46-19-9-7-10-20-46/h7-12,19-22,40-45,48-56,62,109-110H,13-18,23-39,80-82H2,1-6H3,(H2,83,111)(H2,84,112)(H2,85,116)(H,92,113)(H,93,121)(H,94,130)(H,95,114)(H,96,123)(H,97,117)(H,98,122)(H,99,129)(H,100,115)(H,101,118)(H,102,119)(H,103,124)(H,104,125)(H,105,127)(H,106,120)(H,107,126)(H,108,128)(H4,86,87,90)(H4,88,89,91)/t40-,41-,42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,62-/m0/s1
PubChem CID91933712
ChEMBLCHEMBL1631921
IUPHARN/A
BindingDB50333107
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC503.8 nMPMID21067234BindingDB
EC503.802 nMPMID21067234ChEMBL
EC504.0 nMPMID21067234ChEMBL
Emax93.0 %PMID21067234ChEMBL

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