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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesRattus norvegicus (Rat)
GeneHtr7
SynonymGPRFO
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
5-HTx
5-HT7 receptor
5-HT7
[ Show all ]
DiseaseN/A for non-human GPCRs
Length448
Amino acid sequenceMMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProtP32305
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3223
IUPHAR12
DrugBankN/A

Ligand

NameCHEMBL275495
Molecular formulaC21H26N2O
IUPAC name1-[4-(4-methylpiperidin-1-yl)butyl]benzo[cd]indol-2-one
Molecular weight322.452
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP4.3
Synonyms1-[4-(4-Methylpiperidino)butyl]-1,2-dihydrobenzo[cd]indole-2-one
BDBM50403781
Inchi KeyBYFWIELZDBIPDG-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H26N2O/c1-16-10-14-22(15-11-16)12-2-3-13-23-19-9-5-7-17-6-4-8-18(20(17)19)21(23)24/h4-9,16H,2-3,10-15H2,1H3
PubChem CID11301719
ChEMBLCHEMBL275495
IUPHARN/A
BindingDB50403781
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID10843226ChEMBL
Ki>1000.0 nMPMID10843226, PMID14667218BindingDB,ChEMBL

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