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GPCR

NameHistamine H2 receptor
SpeciesMus musculus (Mouse)
GeneHrh2
SynonymGastric receptor I
H2 receptor
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length397
Amino acid sequenceMEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
UniProtP97292
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2245
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL63306
Molecular formulaC18H26N4O
IUPAC name5-[2-(1H-imidazol-5-yl)ethylamino]-N-(4-methylphenyl)hexanamide
Molecular weight314.433
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP2.2
SynonymsN/A
Inchi KeyVURALOBWSBCELU-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H26N4O/c1-14-6-8-16(9-7-14)22-18(23)5-3-4-15(2)20-11-10-17-12-19-13-21-17/h6-9,12-13,15,20H,3-5,10-11H2,1-2H3,(H,19,21)(H,22,23)
PubChem CID13974534
ChEMBLCHEMBL63306
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency4000.0 -PMID2959777ChEMBL

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