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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Free fatty acid receptor 1
Species	Homo sapiens (Human)
Gene	FFAR1
Synonym	FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor
Disease	Type 2 diabetes Non-insulin dependent diabetes Diabetes
Length	300
Amino acid sequence	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProt	O14842
Protein Data Bank	5tzy, 5tzr
GPCR-HGmod model	O14842
3D structure model	This structure is from PDB ID 5tzy.
BioLiP	BL0380462, BL0380463, BL0380464
Therapeutic Target Database	T25608
ChEMBL	CHEMBL4422
IUPHAR	225
DrugBank	BE0000688

Ligand

Name	CHEMBL229225
Molecular formula	C21H26O3
IUPAC name	3-[4-(2-ethylbutoxy)phenyl]-3-phenylpropanoic acid
Molecular weight	326.436
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.1
Synonyms	BDBM22488 SCHEMBL2949713 3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 24 3-[4-(2-ethylbutoxy)phenyl]-3-phenylpropanoic acid
Inchi Key	VYGVLDBVEDZHAD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H26O3/c1-3-16(4-2)15-24-19-12-10-18(11-13-19)20(14-21(22)23)17-8-6-5-7-9-17/h5-13,16,20H,3-4,14-15H2,1-2H3,(H,22,23)
PubChem CID	16738034
ChEMBL	CHEMBL229225
IUPHAR	N/A
BindingDB	22488
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	96.0 %	PMID17500511	ChEMBL
EC50	640.0 nM	PMID17500511	BindingDB
ED50	0.64 uM	PMID17500511	ChEMBL

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