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Name | Free fatty acid receptor 1 |
---|---|
Species | Mus musculus (Mouse) |
Gene | Ffar1 |
Synonym | FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 |
Disease | N/A for non-human GPCRs |
Length | 300 |
Amino acid sequence | MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK |
UniProt | Q76JU9 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5411 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL229225 |
---|---|
Molecular formula | C21H26O3 |
IUPAC name | 3-[4-(2-ethylbutoxy)phenyl]-3-phenylpropanoic acid |
Molecular weight | 326.436 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 5.1 |
Synonyms | 3-[4-(2-ethylbutoxy)phenyl]-3-phenylpropanoic acid BDBM22488 SCHEMBL2949713 3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 24 |
Inchi Key | VYGVLDBVEDZHAD-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H26O3/c1-3-16(4-2)15-24-19-12-10-18(11-13-19)20(14-21(22)23)17-8-6-5-7-9-17/h5-13,16,20H,3-4,14-15H2,1-2H3,(H,22,23) |
PubChem CID | 16738034 |
ChEMBL | CHEMBL229225 |
IUPHAR | N/A |
BindingDB | 22488 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 155.0 % | PMID17500511 | ChEMBL |
EC50 | 2200.0 nM | PMID17500511 | ChEMBL |
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