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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	RACLOPRIDE
Molecular formula	C15H20Cl2N2O3
IUPAC name	3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
Molecular weight	347.236
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.9
Synonyms	(S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide SCHEMBL116054 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide Tox21_110961_1 AB00639928-12 BDBM50005118 CCG-100752 D08CIE GTPL3299 KS-000017HH NCGC00025303-03 NCGC00025303-06 (-)-(S)-3,5-Dichlor-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-hydroxy-o-anisamid Raclopridum 104953-11-9 SR-01000597538-1 430K3SOZ7G [3H]-raclopride AKOS015966951 BN0436 CHEMBL8809 DSSTox_CID_25687 HMS2089C20 MLS001423957 Racloprida (?)- Raclopride S-raclopride 3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide(Raclopride) Tocris-1810 AX8150642 BRD-K04111260-001-05-0 D03GLO DTXSID9045687 HMS3713O20 NCGC00025303-01 NCGC00025303-04 Raclopride [INN:BAN] (S)-3,5-Dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-6-methoxybenzamide SMR000449275 3,5-dichloro-N-{[(2s)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide UNII-430K3SOZ7G AC1MHWAC Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-hydroxy-6-methoxy-, (-)- CHEBI:92070 GTPL94 Meglitinides PDSP1_000924 (-)-(S)-3,5-Dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-hydroxy-o-anisamide Raclopridum [Latin] 3,5-Dichloro-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide SR-01000597538-3 [3H]raclopride ANW-54471 BPBio1_001215 CPD000449275 DSSTox_GSID_45687 HMS2232D05 MolPort-003-983-671 Racloprida [Spanish] (S)-3,5-dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide SAM001247072 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide Tox21_110961 A-40664 B6864 CAS-84225-95-6 D07MEH FLA 870 KB-211375 NCGC00025303-02 NCGC00025303-05 Raclopride;3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide (S)3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide SR-01000597538 ZINC25757754 AJ-32768 Biomol-NT_000027 DB12518 HMS2051C03 MLS000758220 R0094 (-)-raclopride S-(-)-raclopride 3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide (raclopride) TC-143216 84225-95-6 API0006951 BRD-K04111260-001-01-9 CTK8B6813 DSSTox_RID_81059 HMS3268I08 NC00002 [ Show all ]
Inchi Key	WAOQONBSWFLFPE-VIFPVBQESA-N
Inchi ID	InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
PubChem CID	3033769
ChEMBL	CHEMBL8809
IUPHAR	94, 3299
BindingDB	50005118
DrugBank	DB12518
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID2869639	BindingDB

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