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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Ligand

NameRACLOPRIDE
Molecular formulaC15H20Cl2N2O3
IUPAC name3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
Molecular weight347.236
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.9
SynonymsKS-000017HH
NCGC00025303-03
(S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide
SCHEMBL116054
3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
[ Show all ]
Inchi KeyWAOQONBSWFLFPE-VIFPVBQESA-N
Inchi IDInChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
PubChem CID3033769
ChEMBLCHEMBL8809
IUPHAR94, 3299
BindingDB50005118
DrugBankDB12518

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Bmax24.6 pM (mg of protein)-1PMID2966245ChEMBL
IC501.3 nMPMID3172140BindingDB,ChEMBL
IC503.4 nMPMID12361392BindingDB,ChEMBL
IC507.2 nMPMID14592497BindingDB,ChEMBL
IC5014.0 nMPMID3172140BindingDB,ChEMBL
IC5032.0 nMPMID1535660, PMID1973734, PMID1969484, PMID1672158BindingDB,ChEMBL
Kd1.1 nMPMID2966245BindingDB,ChEMBL
Kd1.2 nMPMID4015674IUPHAR
Kd7.1 nMPMID2966245BindingDB,ChEMBL
Ki0.501187 - 19.9526 nMPMID1975644, PMID10617689IUPHAR
Ki1.0 nMPMID11171942BindingDB
Ki1.1 nMPMID8093734, PMID2136916BindingDB,ChEMBL
Ki1.3 nMPMID1969484, PMID1672158BindingDB,ChEMBL
Ki1.8 nMPMID1975644, PMID1840645, PMID2391685BindingDB,ChEMBL
Ki1.99 nMPMID7908055BindingDB
Ki2.6 nMPMID26164842BindingDB,ChEMBL
Ki8.29 nMPMID1827843ChEMBL
Ki8.3 nMPMID1827843BindingDB
Ki9.5 nMPMID1535660BindingDB,ChEMBL
Ki26.0 nMPMID2869639BindingDB
Ki32.0 nMPMID2869639BindingDB
Ki32.8 nMPMID1827843BindingDB,ChEMBL
Ki134.0 nMPMID2869639BindingDB
Ki880.0 nMPMID9021894BindingDB

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