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GLASS

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GPCR

Name	D(3) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd3
Synonym	D3 receptor D3R Dopamine D3 receptor dopaminergic receptor D3
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
UniProt	P19020
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3138
IUPHAR	216
DrugBank	N/A

Ligand

Name	RACLOPRIDE
Molecular formula	C15H20Cl2N2O3
IUPAC name	3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
Molecular weight	347.236
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.9
Synonyms	SCHEMBL116054 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide Tox21_110961_1 AB00639928-12 BDBM50005118 CCG-100752 D08CIE GTPL3299 KS-000017HH NCGC00025303-03 (S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide SR-01000597538-1 430K3SOZ7G [3H]-raclopride AKOS015966951 BN0436 CHEMBL8809 DSSTox_CID_25687 HMS2089C20 MLS001423957 NCGC00025303-06 (-)-(S)-3,5-Dichlor-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-hydroxy-o-anisamid Raclopridum 104953-11-9 3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide(Raclopride) Tocris-1810 AX8150642 BRD-K04111260-001-05-0 D03GLO DTXSID9045687 HMS3713O20 NCGC00025303-01 Racloprida (?)- Raclopride S-raclopride SMR000449275 3,5-dichloro-N-{[(2s)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide UNII-430K3SOZ7G AC1MHWAC Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-hydroxy-6-methoxy-, (-)- CHEBI:92070 GTPL94 Meglitinides NCGC00025303-04 Raclopride [INN:BAN] (S)-3,5-Dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-6-methoxybenzamide SR-01000597538-3 [3H]raclopride ANW-54471 BPBio1_001215 CPD000449275 DSSTox_GSID_45687 HMS2232D05 MolPort-003-983-671 PDSP1_000924 (-)-(S)-3,5-Dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-hydroxy-o-anisamide Raclopridum [Latin] 3,5-Dichloro-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide Tox21_110961 A-40664 B6864 CAS-84225-95-6 D07MEH FLA 870 KB-211375 NCGC00025303-02 Racloprida [Spanish] (S)-3,5-dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide SAM001247072 SR-01000597538 ZINC25757754 AJ-32768 Biomol-NT_000027 DB12518 HMS2051C03 MLS000758220 NCGC00025303-05 Raclopride;3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide (S)3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide 3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide (raclopride) TC-143216 84225-95-6 API0006951 BRD-K04111260-001-01-9 CTK8B6813 DSSTox_RID_81059 HMS3268I08 NC00002 R0094 (-)-raclopride S-(-)-raclopride [ Show all ]
Inchi Key	WAOQONBSWFLFPE-VIFPVBQESA-N
Inchi ID	InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
PubChem CID	3033769
ChEMBL	CHEMBL8809
IUPHAR	94, 3299
BindingDB	50005118
DrugBank	DB12518
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.8 nM	PMID11171942	BindingDB
Ki	3.5 nM	PMID1975644	BindingDB
Ki	9.25 nM	PMID8098771	ChEMBL
Ki	9.3 nM	PMID8098771	BindingDB
Ki	31.6228 nM	PMID1975644	IUPHAR

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