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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMacaca mulatta (Rhesus macaque)
GeneMCHR1
SynonymG-protein coupled receptor 24
MCH receptor 1
MCH-1R
MCH-R1
MCH1R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length388
Amino acid sequenceACAPGQGGRRWRLPQPAWVEGSSAWLWEPATGTGWMDLEASLLPTGPNTSNTSDGPDNLTSAGSPPRSGSVSYINIIMPSVFGTICLLGIIGNSMVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ8MJ89
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2029193
IUPHARN/A
DrugBankN/A

Ligand

NameAMG-076 free base
Molecular formulaC26H33F3N2O2
IUPAC name1-[2-[(4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-1,3,4,4a,5,6,11,11a-octahydropyrido[4,3-b]carbazol-2-yl]ethyl]cyclohexane-1-carboxylic acid
Molecular weight462.557
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP3.8
Synonyms693823-79-9
HX4T7JEV3D
1-(2-((4aR,11R,11aS)-11-methyl-9-(trifluoromethyl)-3,4,4a,5,11,11a-hexahydro-1H-pyrido[4,3-b]carbazol-2(6H)-yl)ethyl)cyclohexanecarboxylic acid
D0X4MC
SCHEMBL2742722
[ Show all ]
Inchi KeyWAOZNBXSEVIAGX-MBOZVWFJSA-N
Inchi IDInChI=1S/C26H33F3N2O2/c1-16-20-15-31(12-10-25(24(32)33)8-3-2-4-9-25)11-7-17(20)13-22-23(16)19-14-18(26(27,28)29)5-6-21(19)30-22/h5-6,14,16-17,20,30H,2-4,7-13,15H2,1H3,(H,32,33)/t16-,17-,20-/m1/s1
PubChem CID10004545
ChEMBLCHEMBL2032049
IUPHARN/A
BindingDB50383522
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC500.8 nMPMID22542010BindingDB,ChEMBL

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