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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	CHEMBL187621
Molecular formula	C34H38N4O
IUPAC name	(E)-N-[2-(dimethylamino)ethyl]-3-phenyl-N-[[6-[4-[(2-phenylethylamino)methyl]phenyl]pyridin-3-yl]methyl]prop-2-enamide
Molecular weight	518.705
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.3
Synonyms	N/A
Inchi Key	CAHJBZZIWHFJHP-CAPFRKAQSA-N
Inchi ID	InChI=1S/C34H38N4O/c1-37(2)23-24-38(34(39)20-16-28-9-5-3-6-10-28)27-31-15-19-33(36-26-31)32-17-13-30(14-18-32)25-35-22-21-29-11-7-4-8-12-29/h3-20,26,35H,21-25,27H2,1-2H3/b20-16+
PubChem CID	11352884
ChEMBL	CHEMBL187621
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	25.12 nM	PMID16002289	ChEMBL

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