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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesMus musculus (Mouse)
GeneHcar2
SynonymProtein PUMA-G
Nicotinic acid receptor
Nic1
Niacr1
niacin receptor 1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length360
Amino acid sequenceMSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
UniProtQ9EP66
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4420
IUPHAR312
DrugBankN/A

Ligand

NameCHEMBL500239
Molecular formulaC10H14N6
IUPAC name5-propyl-3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
Molecular weight218.264
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.7
Synonyms5-propyl-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
BDBM50277671
SCHEMBL5442910
Inchi KeyWGXZDWDHFVAHOI-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H14N6/c1-2-3-6-4-7-8(5-6)11-12-9(7)10-13-15-16-14-10/h6H,2-5H2,1H3,(H,11,12)(H,13,14,15,16)
PubChem CID11424509
ChEMBLCHEMBL500239
IUPHARN/A
BindingDB50277671
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50260.0 nMPMID19307116BindingDB,ChEMBL

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