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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesRattus norvegicus (Rat)
GeneHtr2a
Synonym5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
'D' receptor
5-HT-2A
serotonin receptor 2A
5Ht-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length471
Amino acid sequenceMEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProtP14842
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL322
IUPHAR6
DrugBankN/A

Ligand

NameCHEMBL1173017
Molecular formulaC29H39N5
IUPAC name4-[4-[6-(4-phenylpiperazin-1-yl)hexyl]piperazin-1-yl]quinoline
Molecular weight457.666
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP5.2
SynonymsSCHEMBL4527749
BDBM50322370
4-(4-(6-(4-phenylpiperazin-1-yl)hexyl)piperazin-1-yl)quinoline
Inchi KeyAEQHEVDDTLOOMD-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H39N5/c1(8-16-31-18-22-33(23-19-31)26-10-4-3-5-11-26)2-9-17-32-20-24-34(25-21-32)29-14-15-30-28-13-7-6-12-27(28)29/h3-7,10-15H,1-2,8-9,16-25H2
PubChem CID11539823
ChEMBLCHEMBL1173017
IUPHARN/A
BindingDB50322370
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki34.0 nMPMID20481570BindingDB,ChEMBL

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