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Name | P2Y purinoceptor 14 |
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Species | Homo sapiens (Human) |
Gene | P2RY14 |
Synonym | G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 [ Show all ] |
Disease | N/A |
Length | 338 |
Amino acid sequence | MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL |
UniProt | Q15391 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q15391 |
3D structure model | This predicted structure model is from GPCR-EXP Q15391. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4518 |
IUPHAR | 330 |
DrugBank | N/A |
Name | CHEMBL611791 |
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Molecular formula | C16H31N3O10P2S |
IUPAC name | N,N-diethylethanamine;[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]methylphosphonic acid |
Molecular weight | 519.443 |
Hydrogen bond acceptor | 12 |
Hydrogen bond donor | 6 |
XlogP | None |
Synonyms | N/A |
Inchi Key | WKIGMBRNXRUKRS-BKZSBQMKSA-N |
Inchi ID | InChI=1S/C10H16N2O10P2S.C6H15N/c13-6-1-2-12(10(25)11-6)9-8(15)7(14)5(22-9)3-21-24(19,20)4-23(16,17)18;1-4-7(5-2)6-3/h1-2,5,7-9,14-15H,3-4H2,(H,19,20)(H,11,13,25)(H2,16,17,18);4-6H2,1-3H3/t5-,7-,8-,9-;/m1./s1 |
PubChem CID | 44627487 |
ChEMBL | CHEMBL611791 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.92 nM | PMID19902968 | ChEMBL |
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