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GPCR

Name5-hydroxytryptamine receptor 1F
SpeciesHomo sapiens (Human)
GeneHTR1F
Synonym5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
serotonin receptor 1F
5-HT-1F
5-HT1Ebeta
HTR1EL
[ Show all ]
DiseaseMigraine
Length366
Amino acid sequenceMDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
UniProtP30939
Protein Data BankN/A
GPCR-HGmod modelP30939
3D structure modelThis predicted structure model is from GPCR-EXP P30939.
BioLiPN/A
Therapeutic Target DatabaseT78656
ChEMBLCHEMBL1805
IUPHAR5
DrugBankBE0000460, BE0004958

Ligand

Name5-Carboxamidotryptamine
Molecular formulaC11H13N3O
IUPAC name3-(2-aminoethyl)-1H-indole-5-carboxamide
Molecular weight203.245
Hydrogen bond acceptor2
Hydrogen bond donor3
XlogP-0.6
Synonyms1H-Indole-5-carboxamide, 3-(2-aminoethyl)-
1H-Indole-5-carboxamide,3-(2-aminoethyl)-
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
3-(2-aminoethyl)-1H-indole-5-carboxamide
3-(2-aminoethyl)-1h-indole-5-carboxylic acid amide
[ Show all ]
Inchi KeyWKZLNEWVIAGNAW-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)
PubChem CID1809
ChEMBLCHEMBL18840
IUPHAR4
BindingDB21392
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki717.0 nMPMID8380639PDSP,BindingDB
Ki724.43 nMPMID7984267PDSP,BindingDB
Ki794.328 nMPMID8380639, PMID9225282IUPHAR

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