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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesHomo sapiens (Human)
GeneHCAR2
SynonymG-protein coupled receptor HM74A
G-protein coupled receptor 109A
PUMAG
Nicotinic acid receptor
HCA2 receptor
[ Show all ]
DiseaseHyperlipidaemia
Acute ischemic stroke
Arteriosclerosis
Atherosclerosis
Cardiovascular disorder
[ Show all ]
Length363
Amino acid sequenceMNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProtQ8TDS4
Protein Data BankN/A
GPCR-HGmod modelQ8TDS4
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDS4.
BioLiPN/A
Therapeutic Target DatabaseT00864
ChEMBLCHEMBL3785
IUPHAR312
DrugBankBE0000635

Ligand

NameCHEMBL235741
Molecular formulaC22H19NO3
IUPAC name2-[3-(4-phenylphenyl)propanoylamino]benzoic acid
Molecular weight345.398
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP5.4
Synonyms2-(3-biphenyl-4-yl-propionylamino)-benzoic acid
2-[3-(4-phenylphenyl)propanamido]benzoic acid
BDBM23519
Biaryl Anthranilide Analogue, 1c
D01AUX
[ Show all ]
Inchi KeyCAYOKBAXZPGNTO-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H19NO3/c24-21(23-20-9-5-4-8-19(20)22(25)26)15-12-16-10-13-18(14-11-16)17-6-2-1-3-7-17/h1-11,13-14H,12,15H2,(H,23,24)(H,25,26)
PubChem CID11617151
ChEMBLCHEMBL235741
IUPHARN/A
BindingDB23519
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50590.0 nMPMID17994679, PMID19309152BindingDB,ChEMBL
IC5094.0 nMPMID17994679BindingDB,ChEMBL
IC50290.0 nMPMID25737085ChEMBL
Ratio0.78 -PMID25737085ChEMBL

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