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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Type-1B angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr1b
Synonym	Angiotensin II type-1B receptor AT1B AT3
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
UniProt	P29089
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL263
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL314799
Molecular formula	C23H25N7O
IUPAC name	2-butyl-5-[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-one
Molecular weight	415.501
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.6
Synonyms	BDBM50283558 2-Butyl-5-[2''-(2H-tetrazol-5-yl)-biphenyl-4-yl]-5,6,7,8-tetrahydro-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one
Inchi Key	CAYZWFPFTMLBBH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25N7O/c1-2-3-15-29-23(31)30-20(9-6-10-21(30)26-29)17-13-11-16(12-14-17)18-7-4-5-8-19(18)22-24-27-28-25-22/h4-5,7-8,11-14,20H,2-3,6,9-10,15H2,1H3,(H,24,25,27,28)
PubChem CID	44320916
ChEMBL	CHEMBL314799
IUPHAR	N/A
BindingDB	50283558
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	, Bioorg. Med. Chem. Lett., (1994) 4:21:2591	BindingDB,ChEMBL

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