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GLASS

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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL152348
Molecular formula	C25H20ClN3O4S
IUPAC name	N-[(E)-[4-[[2-(1-benzothiophen-3-yl)acetyl]amino]-3-methoxyphenyl]methylideneamino]-3-chloro-4-hydroxybenzamide
Molecular weight	493.962
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	4.9
Synonyms	BDBM50122115 2-Benzo[b]thiophen-3-yl-N-{4-[(3-chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-2-methoxy-phenyl}-acetamide
Inchi Key	CBBZAZSQKGEJOQ-UVHMKAGCSA-N
Inchi ID	InChI=1S/C25H20ClN3O4S/c1-33-22-10-15(13-27-29-25(32)16-7-9-21(30)19(26)11-16)6-8-20(22)28-24(31)12-17-14-34-23-5-3-2-4-18(17)23/h2-11,13-14,30H,12H2,1H3,(H,28,31)(H,29,32)/b27-13+
PubChem CID	44369100
ChEMBL	CHEMBL152348
IUPHAR	N/A
BindingDB	50122115
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	63.2 nM	PMID12477359	BindingDB,ChEMBL

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