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GPCR

NameMuscarinic acetylcholine receptor M5
SpeciesHomo sapiens (Human)
GeneCHRM5
SynonymM5R
M5 receptor
cholinergic receptor
cholinergic receptor, muscarinic 5
DiseaseUrinary incontinence
Colitis
Dysmenorrhea
Irritable bowel syndrome
Myasthenia gravis
[ Show all ]
Length532
Amino acid sequenceMEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProtP08912
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT79961
ChEMBLCHEMBL2035
IUPHAR17
DrugBankBE0000247, BE0004890

Ligand

NamePecazine
Molecular formulaC19H22N2S
IUPAC name10-[(1-methylpiperidin-3-yl)methyl]phenothiazine
Molecular weight310.459
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.6
SynonymsNCIOpen2_008134
Pakatal
Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-
US9504692, Mepezine
10-(1-Methyl-3-piperidyl)methyl phenothiazine
[ Show all ]
Inchi KeyCBHCDHNUZWWAPP-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3
PubChem CID6075
ChEMBLCHEMBL395110
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5040.0 nMDrugMatrix in vitro pharmacology dataChEMBL
Ki28.0 nMDrugMatrix in vitro pharmacology dataChEMBL

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