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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger2
Synonym	EP2 receptor PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
UniProt	Q62928
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4909
IUPHAR	341
DrugBank	N/A

Ligand

Name	CHEMBL541517
Molecular formula	C24H28N2O4S2
IUPAC name	3-[3-[[(4-tert-butylphenyl)methyl-(1,3-thiazol-2-ylsulfonyl)amino]methyl]phenyl]propanoic acid
Molecular weight	472.618
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	4.9
Synonyms	BDBM50293495 SCHEMBL5043203 3-(3-((N-(4-tert-butylbenzyl)thiazole-2-sulfonamido)methyl)phenyl)propanoic acid
Inchi Key	WVDZQCYXZZHZIL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H28N2O4S2/c1-24(2,3)21-10-7-19(8-11-21)16-26(32(29,30)23-25-13-14-31-23)17-20-6-4-5-18(15-20)9-12-22(27)28/h4-8,10-11,13-15H,9,12,16-17H2,1-3H3,(H,27,28)
PubChem CID	18376082
ChEMBL	CHEMBL541517
IUPHAR	N/A
BindingDB	50293495
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.1 nM	PMID19250823	BindingDB,ChEMBL
IC50	63.0 nM	PMID19250823	BindingDB,ChEMBL

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