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GLASS

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GPCR

Name	Alpha-2B adrenergic receptor
Species	Oryctolagus cuniculus (Rabbit)
Gene	ADRA2B
Synonym	Alpha-2B adrenoceptor Alpha-2B adrenoreceptor Alpha-2BAR
Disease	N/A for non-human GPCRs
Length	394
Amino acid sequence	AIAAVITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNCKRTPRRIKCIILTVWLIAAAISLPPLIYKGDQGPQPHGAPQCKLNQEAWYILSSSLGSFFVPCLIMILVYLRIYLIAKRSHRRGPRAKGGPGEGESRQACPVPGGPSASAKLPTLATPVASASEANGPSKPAGEKEEGETPEDPGTQALPPGWATLPNSGQGQKEGVSGASLEEEAEEEEEEEEEEDEPQAVPVSPASVGSPPLQQPQGSRVLATLRGQVLVGRGVGAMSGQWWRRRAQLSREKRFTFVLAVVIGVFVLCWFPFFFSYSLSAICPQQCRVPHGLF
UniProt	O77830
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	oxymetazoline
Molecular formula	C16H24N2O
IUPAC name	6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
Molecular weight	260.381
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.9
Synonyms	1491-59-4 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline 3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-6-tert-butyl-phenol 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol 6-tert-butyl-3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,4-dimethylphenol 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenol;hydrochloride 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol;hydrochloride 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol # 8VLN5B44ZY AB00053513-12 AB00053513-13 AB00053513_14 AB00053513_15 AC-6370 AC1L1IM1 Afrin Afrin Cherry 12 Hour Nasal Spray Afrin Extra Moisturizing 12 Hour Nasal Spray Afrin Original 12 Hour Nasal Spray Afrin Original 12 Hour Nose Drops Afrin Original 12 Hour Pump Mist Afrin Sinus 12 Hour Nasal Spray Afrin, Dristan12-hrnasalspray, Ocuclear, Drixine AJ-09693 AK113123 AKOS007930348 AN-10265 BDBM30712 Biomol-NT_000161 BPBio1_000295 BPBio1_000419 BRD-K16195444-001-01-7 BRD-K16195444-003-16-1 BRN 0886303 BSPBio_000267 BSPBio_002145 C-16261 C07363 CAS-1491-59-4 CAS-151615 CC-33432 CCG-204985 CHEBI:7862 CHEMBL762 cid_66259 D08322 D09EBS DB00935 Decongestant (TN) DivK1c_000567 Dristan Long Lasting Mentholated Nasal Spray Dristan Long Lasting Nasal Mist Drixoral Nasal Solution DSSTox_CID_20691 DSSTox_GSID_40691 DSSTox_RID_79545 DTXSID3040691 Duramist Plus Up To 12 Hour Nasal Decongestant Spray EINECS 216-079-1 FT-0082560 FT-0601532 FT-0650596 Genasal Nasal Spray Up to 12 Hour Relief GTPL124 H 990 H-990 Hazol HMS2089G03 HSDB 3143 IDI1_000567 Iliadin KB-302508 KBio1_000567 KBio2_001531 KBio2_004099 KBio2_006667 KBio3_001645 KBioGR_000908 KBioSS_001531 L000459 Lopac-O-2378 Lopac0_000903 LS-104146 MCULE-8690625159 Nafrine Nasal Relief 12 Hour Nasal Spray Nasivine (Salt/Mix) Navasin Navisin NCGC00015766-01 NCGC00015766-02 NCGC00015766-03 NCGC00015766-04 NCGC00015766-05 NCGC00015766-06 NCGC00015766-07 NCGC00015766-08 NCGC00015766-09 NCGC00015766-10 NCGC00015766-11 NCGC00015766-13 NCGC00015766-16 NCGC00022345-02 NCGC00022345-04 NCGC00022345-05 NCGC00022345-06 Neo-Synephrine 12 Hour Spray Nezeril NINDS_000567 Nostrilla 12 Hour Nasal Decongestant Operil (TN) Oximetazolina Oximetazolina [INN-Spanish] Oximetazolinum Oxylazine oxymeta zoline oxymetazolina Oxymetazoline (INN) oxymetazoline hydrochloride crystalline Oxymetazoline [INN:BAN] Oxymetazolinum Oxymetazolinum [INN-Latin] Oxymethazoline Oxymetozoline Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl- Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl- Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl- (9CI) Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-(9CI) Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl- Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl- Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl- (7CI,8CI) Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-(7CI,8CI) Phenol,3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl- Prestwick0_000224 Prestwick1_000224 Prestwick2_000224 Prestwick3_000224 Rhinofrenol Rhinolitan SBI-0050878.P004 SCH-9384 SCHEMBL24301 Sinerol SPBio_001095 SPBio_002188 Spectrum2_000998 Spectrum3_000533 Spectrum4_000464 Spectrum5_001114 Spectrum_001051 STK075254 Tocris-1142 Tox21_110217 Tox21_110217_1 UNII-8VLN5B44ZY Vicks Sinex Vicks Sinex 12 Hour Nasal Spray Vicks Sinex 12 Hour Ultra Fine Mist for Sinus Relief Visine L.R Visine L.R. WYWIFABBXFUGLM-UHFFFAOYSA-N ZINC57435 [ Show all ]
Inchi Key	WYWIFABBXFUGLM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)
PubChem CID	4636
ChEMBL	CHEMBL762
IUPHAR	124
BindingDB	30712
DrugBank	DB00935
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.5 nM	PMID11408545	BindingDB
Ki	6.3 nM	PMID11408545	BindingDB

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