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GPCR

NameMu-type opioid receptor
SpeciesHomo sapiens (Human)
GeneOPRM1
SynonymhMOP
M-OR-1
MOP
opioid receptor, mu 1
opioid receptor
[ Show all ]
DiseaseDiarrhea
Inflammatory disease
Pain
Major depressive disorder
Migraine
[ Show all ]
Length400
Amino acid sequenceMDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProtP35372
Protein Data BankN/A
GPCR-HGmod modelP35372
3D structure modelThis predicted structure model is from GPCR-EXP P35372.
BioLiPN/A
Therapeutic Target DatabaseT47768
ChEMBLCHEMBL233
IUPHAR319
DrugBankBE0000770

Ligand

NameCHEMBL228740
Molecular formulaC22H23NOS
IUPAC name4-phenyl-1-[phenyl(thiophen-2-yl)methyl]piperidin-4-ol
Molecular weight349.492
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.3
Synonyms4-phenyl-1-(phenyl(thiophen-2-yl)methyl)piperidin-4-ol
BDBM50210399
Inchi KeyAEUSAZUUXLNHOA-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H23NOS/c24-22(19-10-5-2-6-11-19)13-15-23(16-14-22)21(20-12-7-17-25-20)18-8-3-1-4-9-18/h1-12,17,21,24H,13-16H2
PubChem CID44426824
ChEMBLCHEMBL228740
IUPHARN/A
BindingDB50210399
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki405.0 nMPMID17428659BindingDB,ChEMBL

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