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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	MLS001197120
Molecular formula	C24H20N2O4
IUPAC name	N-[2-methoxy-4-[(3-methylbenzoyl)amino]phenyl]-1-benzofuran-2-carboxamide
Molecular weight	400.434
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.7
Synonyms	Oprea1_542435 BDBM66780 N-[2-methoxy-4-(m-toluoylamino)phenyl]coumarilamide SR-01000458348-1 cid_3962444 N-[2-methoxy-4-[[(3-methylphenyl)-oxomethyl]amino]phenyl]-2-benzofurancarboxamide AC1N0GE1 MolPort-002-938-834 SMR000555532 N-[2-methoxy-4-[(3-methylbenzoyl)amino]phenyl]-1-benzofuran-2-carboxamide STK061503 MCULE-8890457294 N-{2-methoxy-4-[(3-methylbenzoyl)amino]phenyl}-1-benzofuran-2-carboxamide AKOS001661591 N-(2-methoxy-4-{[(3-methylphenyl)carbonyl]amino}phenyl)-1-benzofuran-2-carboxamide SR-01000458348 CHEMBL1596869 N-[2-methoxy-4-[(3-methylphenyl)carbonylamino]phenyl]-1-benzofuran-2-carboxamide ZINC5754995 [ Show all ]
Inchi Key	CCNCCGSRFQMVNQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H20N2O4/c1-15-6-5-8-17(12-15)23(27)25-18-10-11-19(21(14-18)29-2)26-24(28)22-13-16-7-3-4-9-20(16)30-22/h3-14H,1-2H3,(H,25,27)(H,26,28)
PubChem CID	3962444
ChEMBL	CHEMBL1596869
IUPHAR	N/A
BindingDB	66780
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<92448.0 nM	PubChem BioAssay data set	ChEMBL

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