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GPCR

NameHistamine H2 receptor
SpeciesCavia porcellus (Guinea pig)
GeneHRH2
SynonymGastric receptor I
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProtP47747
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2882
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL553806
Molecular formulaC13H19ClN8O2S2
IUPAC name1-[[6-[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]pyridin-2-yl]methyl]-2-methyl-3-methylsulfonylguanidine;hydrochloride
Molecular weight418.919
Hydrogen bond acceptor7
Hydrogen bond donor5
XlogPNone
SynonymsSCHEMBL9297680
Inchi KeyCCQLTPZTMOZRSM-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H18N8O2S2.ClH/c1-16-12(21-25(2,22)23)17-6-8-4-3-5-9(18-8)10-7-24-13(19-10)20-11(14)15;/h3-5,7H,6H2,1-2H3,(H2,16,17,21)(H4,14,15,19,20);1H
PubChem CID18953947
ChEMBLCHEMBL553806
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition29.0 %PMID7904648ChEMBL

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