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GPCR

NameVasopressin V2 receptor
SpeciesBos taurus (Bovine)
GeneAVPR2
SynonymAntidiuretic hormone receptor
AVPR V2
Renal-type arginine vasopressin receptor
V2R
DiseaseN/A for non-human GPCRs
Length370
Amino acid sequenceMFMASTTSAVPWHLSQPTPAGNGSEGELLTARDPLLAQAELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAHRHGGGTHWNRPVLLAWAFSLLFSLPQLFIFAQRDVDGSGVLDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLGPGPVPRAGGPRRGCRPGSPAEGARVSAAVAKTVKMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCTWRRAPPSPGPQEESCATASSFLAKDTPS
UniProtP48044
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2344
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL438387
Molecular formulaC51H74N14O12S2
IUPAC name(10R,13S,16S,19S,22S)-13-(2-amino-2-oxoethyl)-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-16-(3-amino-3-oxopropyl)-19-benzyl-22-[(4-ethoxyphenyl)methyl]-N-methyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carboxamide
Molecular weight1139.36
Hydrogen bond acceptor15
Hydrogen bond donor12
XlogP-2.2
Synonyms[Mca1,D-Tyr(OEt)2,Sar7]AVP
BDBM50030088
Inchi KeyXDGHQNNQRUGCLN-JPRYDEJLSA-N
Inchi IDInChI=1S/C51H74N14O12S2/c1-3-77-32-16-14-31(15-17-32)24-35-46(73)62-36(23-30-11-6-4-7-12-30)47(74)61-34(18-19-39(52)66)45(72)63-37(25-40(53)67)48(75)64-38(29-78-79-51(26-42(69)60-35)20-8-5-9-21-51)49(76)65(2)28-43(70)59-33(13-10-22-57-50(55)56)44(71)58-27-41(54)68/h4,6-7,11-12,14-17,33-38H,3,5,8-10,13,18-29H2,1-2H3,(H2,52,66)(H2,53,67)(H2,54,68)(H,58,71)(H,59,70)(H,60,69)(H,61,74)(H,62,73)(H,63,72)(H,64,75)(H4,55,56,57)/t33-,34-,35-,36-,37-,38-/m0/s1
PubChem CID44320718
ChEMBLCHEMBL438387
IUPHARN/A
BindingDB50030088
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Kd29.0 nMPMID7507528BindingDB,ChEMBL

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