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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucagon receptor
Species	Mus musculus (Mouse)
Gene	Gcgr
Synonym	GGR GL-R glucagon receptor GR
Disease	N/A for non-human GPCRs
Length	485
Amino acid sequence	MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT
UniProt	Q61606
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4773
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	aminothiazole, 17
Molecular formula	C27H21ClF3N3O4S
IUPAC name	3-[[4-[(4-chloro-N-[4-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]anilino)methyl]benzoyl]amino]propanoic acid
Molecular weight	575.987
Hydrogen bond acceptor	10
Hydrogen bond donor	2
XlogP	6.7
Synonyms	3-[4-({(4-Chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid XEECUIDWJQYSIO-UHFFFAOYSA-N CHEMBL519776 3-[4-({(4-Chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)-benzoylamino]propionic Acid BDBM29120 SCHEMBL2647625 [ Show all ]
Inchi Key	XEECUIDWJQYSIO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H21ClF3N3O4S/c28-20-7-9-21(10-8-20)34(15-17-1-3-19(4-2-17)25(37)32-14-13-24(35)36)26-33-23(16-39-26)18-5-11-22(12-6-18)38-27(29,30)31/h1-12,16H,13-15H2,(H,32,37)(H,35,36)
PubChem CID	10053886
ChEMBL	CHEMBL519776
IUPHAR	N/A
BindingDB	29120
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	418.0 nM	PMID19385613	ChEMBL

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